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| Autor: | Jose Luis Lopez-Guerra, Pedro Bilbao, P. Willisch, C. Carvajal, Alfonso Gomez-Iturriaga, V. Morillo, E. Hortelano, Ana Irasarri, Arturo Navarro, Francisco Casquero, Jose Ignacio Pijoan, Ana Illescas, Jon Cacicedo, Olga del Hoyo, Raquel Ciervide |
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| Přispěvatelé: | [Gomez-Iturriaga,A, Cacicedo,J, Carvajal,C, Hortelano,E, Casquero,F, Del Hoyo,O, Bilbao,P] Department of Radiation Oncology, Hospital Universitario Cruces/ Biocruces Health Research Institute, Barakaldo, Spain. [Navarro,A] Department of Radiation Oncology, Instituto Catalan de Oncología, L'Hospitalet de Llobregat, Barcelona, Spain. [Morillo,V] Department of Radiation Oncology, Hospital de Castellón, Castelló de la Plana, Castelló, Spain. [Willisch,P] Department of Radiation Oncology, Hospital Meixoeiro, Vigo, Pontevedra, Spain. [Lopez-Guerra,JL] Department of Radiation Oncology, Hospital Virgen Del Rocío, Sevilla, Spain. [Illescas,A] Department of Radiation Oncology, Hospital Virgen Macarena, Sevilla, Spain. [Ciervide,R] Department of Radiation Oncology, Hospital San Chinarro, Madrid, Spain. [Irasarri,A, Pijoan,JI] Clinical Epidemiology Unit, Hospital Universitario Cruces/ Biocruces Heatlh Research Institute, Barakaldo, Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Palliative care Anatomy::Urogenital System::Genitalia::Genitalia Male::Prostate [Medical Subject Headings] Pain medicine medicine.medical_treatment Analgesic Pain Check Tags::Male [Medical Subject Headings] Bone Neoplasms Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Radioterapia Information Science::Information Science::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings] Internal medicine Palliative radiotherapy Medicine Humans Prospective Studies Brief Pain Inventory Neoplasm Metastasis Prospective cohort study Bone pain Aged Medicine(all) Aged 80 and over Radiotherapy business.industry Incidence (epidemiology) Bone metastases Palliative Care Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Follow-Up Studies [Medical Subject Headings] General Medicine Middle Aged Diseases::Nervous System Diseases::Neurologic Manifestations::Pain [Medical Subject Headings] Surgery Radiation therapy Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics [Medical Subject Headings] Check Tags::Female [Medical Subject Headings] Dolor irruptivo Female medicine.symptom Neoplasias óseas Diseases::Neoplasms::Neoplasms by Site::Bone Neoplasms [Medical Subject Headings] business Pain flare Research Article |
| Zdroj: | BMC Palliative Care |
| Popis: | Journal Article; Research Support, Non-U.S. Gov't; BACKGROUND Palliative radiotherapy (RT) is an effective treatment for symptomatic bone metastases. Pain flare, a transient worsening of the bone pain after RT, has been described in previous reports with different incidence rates. The aim of the study was to prospectively evaluate the incidence of pain flare following RT for painful bone metastases and evaluate its effects on pain control and functionality of the patients. METHODS Between June 2010 and June 2014, 204 patients were enrolled in this study and 135 patients with complete data were evaluable. Pain flare was defined as a 2- point increase in worst pain score as compared with baseline with no decrease in analgesic intake or a 25% increase in analgesic intake as compared with baseline with no decrease in worst pain score. All pain medications and worst pain scores were collected before, daily during, and for 10 days after RT. The Brief Pain Inventory (BPI) was filled out on the pretreatment and at the 4 weeks follow-up visit. RESULTS There were 90 men (66.7%) and 45 women (33.3%). Mean age was 66 years (SD 9.8). The most common primary cancer site was lung in 42 patients (31.1%), followed by prostate in 27 patients (20.0%). Forty-two patients (31.1%) patients received a single fraction of 8 Gy and 83 (61.5%) received 20 Gy in five fractions. The overall pain flare incidence across all centers was 51/135 (37.7%). The majority of pain flares occurred on days 1-5 (88.2%). The mean duration of the pain flare was 3 days (SD: 3). There were no significant relationships between the occurrence of pain flare and collected variables. All BPI items measured four weeks after end of RT showed significant improvement as compared with pretreatment scores (p |
| Databáze: | OpenAIRE |
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