Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations
| Autor: | Claire Welton, Parth Raval, Julien Trébosc, G. N. Manjunatha Reddy |
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| Přispěvatelé: | Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut Michel Eugène Chevreul - FR 2638 (IMEC), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Project: 795091,H2020,H2020-MSCA-IF-2017,ZEOCATALYST(2019) |
| Rok vydání: | 2022 |
| Předmět: |
Dopamine
Metals and Alloys [CHIM.THER]Chemical Sciences/Medicinal Chemistry General Chemistry [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences Deuterium Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Pharmaceutical Preparations [CHIM.ANAL]Chemical Sciences/Analytical chemistry Materials Chemistry Ceramics and Composites Amino Acids Protons |
| Zdroj: | Chemical Communications Chemical Communications, 2022, 58 (82), pp.11551-11554. ⟨10.1039/D2CC04585K⟩ |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | International audience; Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by 1H–2H isotope correlation NMR spectroscopy (iCOSY). A minuscule concentration of dopamine, 5 wt% or ∼100 μg, in a solid formulation can be detected by 2H NMR at 28.2 T (1H, 1200 MHz) in under a minute. |
| Databáze: | OpenAIRE |
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