C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population
| Autor: | Juanita Romero-Diaz, Guadalupe Lima, Yemil Atisha-Fregoso, Luis Llorente, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Juan Jakez-Ocampo, Gilberto Vargas-Alarcón, Alejandra Iturralde-Chávez, José Manuel Rodríguez-Pérez, Eduardo Carrillo-Maravilla, Nora Hernández-Díaz, Miguel Baños-Peláez |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Genotype Pcr assay Lower risk Polymorphism Single Nucleotide Gastroenterology 03 medical and health sciences 0302 clinical medicine Gene Frequency Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic SNP Genetic Predisposition to Disease Mexico 030203 arthritis & rheumatology Systemic lupus erythematosus biology business.industry C-reactive protein Haplotype General Medicine medicine.disease Mexican population C-Reactive Protein 030104 developmental biology Haplotypes Case-Control Studies biology.protein Female business Polymorphism Restriction Fragment Length |
| Zdroj: | Clinical Rheumatology. 37:1817-1824 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s10067-018-4059-5 |
| Popis: | To evaluate the association of C-reactive protein (CRP) polymorphisms with risk of development SLE in a group of Mexican individuals. Five CRP polymorphisms (rs3093059, rs3093062, rs1800947, rs1130864, and rs1205) were determined by PCR-restriction fragment length polymorphism and SNP rs3093061 by refractory mutation system PCR assay in 126 SLE patients and 131 controls. Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032). The rs3091244 polymorphism was associated with decreased risk of SLE mostly under additive (OR = 0.605, 95% CI 0.393-0.931. P = 0.022) model. Our study establishes that rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing SLE. |
| Databáze: | OpenAIRE |
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