Muc-1 expression may help characterize thyroid nodules but does not predict patients' outcome
| Autor: | Laura Sterian Ward, Lucas Leite Cunha, José Vassallo, Ana Carolina Trindade Guilhen, Joyce do Rosario da Silva, Elaine Cristina Morari, Fernando Augusto Soares, Marjory Alana Marcello |
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| Rok vydání: | 2010 |
| Předmět: |
Thyroid nodules
Adult Male endocrine system Pathology medicine.medical_specialty endocrine system diseases Adolescent Endocrinology Diabetes and Metabolism Biology Sensitivity and Specificity Pathology and Forensic Medicine Metastasis Thyroid carcinoma Young Adult Endocrinology Follicular phase Adenocarcinoma Follicular medicine Biomarkers Tumor Humans RNA Messenger Thyroid Neoplasms Thyroid Nodule skin and connective tissue diseases Child neoplasms Thyroid cancer Pathological Aged Neoplasm Staging Aged 80 and over Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Thyroid Mucin-1 General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Carcinoma Papillary medicine.anatomical_structure Female |
| Zdroj: | Endocrine pathology. 21(4) |
| ISSN: | 1559-0097 |
| Popis: | Our purpose was to evaluate MUC1 clinical utility in the diagnosis and prognosis of thyroid cancer patients. We studied the protein expression of MUC1 in 289 thyroid carcinomas and 121 noncancerous thyroid nodules. There were 41 follicular carcinomas (FC) and 248 papillary thyroid carcinomas (PTC) including 149 classic (CPTC), 20 tall cell (TCPTC) and 79 follicular variants (FVPTC). In addition, we used a quantitative real-time PCR (q-PCR) method to measure MUC1 mRNA expression levels in 108 carcinomas, 23 hyperplasias, and 19 FA. According to their serum Tg levels and other evidences of recurrence/metastasis, the patients were classified as free-of-disease (185 cases) or bad outcome (56 cases, 10 deaths). MUC1 protein was identified in 80.2% PTC; 48.8% FC; 68.3% FVPTC; 70% TCPTC; 21.8% FA; 30% hyperplasias and 6% normal thyroid tissues. MUC1 distinguished benign from malignant thyroid tissues (sensitivity = 89%; specificity = 53%). MUC1 also differentiated FC from FA (p = 0.0083). q-PCR mRNA expression of MUC1 also distinguished malignant from benign nodules (Mann–Whitney test, p < 0.0001). However, neither IHC nor mRNA MUC1 expression was associated with any clinical or pathological feature of aggressiveness or outcome. We suggest that MUC1 expression may help differentiate follicular patterned thyroid lesions. |
| Databáze: | OpenAIRE |
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