pH/NIR-responsive semiconducting polymer nanoparticles for highly effective photoacoustic image guided chemo-photothermal synergistic therapy
| Autor: | Yunfei Liu, Biqing Bao, Yu Xu, Lianhui Wang, Peng Su, Bingbing Gu, Jia Chen, Li Tong |
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| Rok vydání: | 2019 |
| Předmět: |
Light
Cell Survival Polymers Mice Nude Pharmaceutical Science Nanoparticle Nanotechnology 02 engineering and technology Photoacoustic Techniques 03 medical and health sciences Neoplasms Animals Humans 030304 developmental biology chemistry.chemical_classification Mice Inbred BALB C 0303 health sciences Antibiotics Antineoplastic Photothermal effect technology industry and agriculture Chain transfer Raft Polymer Hydrogen-Ion Concentration Photothermal therapy 021001 nanoscience & nanotechnology Drug Liberation Photochemotherapy chemistry Polymerization Doxorubicin Drug delivery Nanoparticles Female 0210 nano-technology HeLa Cells |
| Zdroj: | Journal of Controlled Release. 293:94-103 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2018.11.016 |
| Popis: | Multifunctional drug delivery nanoplatform (PDPP3T@PSNiAA NPs) based on NIR absorbing semiconducting polymer nanoparticles for pH/NIR light-controllably regulated drug release has been successfully prepared. In this strategy, pH/thermal-sensitive multifunctional polymer polystyrene-b-poly(N-isopropylacrylamide-co-acrylic acid) (PSNiAA) was meticulously designed and synthesized using the reversible addition fragmentation chain transfer (RAFT) polymerization method. Furthermore, PSNiAA was used to functionalize diketopyrrolopyrrole-based semiconducting polymer (PDPP3T) to combine photothermal capacity and pH/thermo-responsive drug release in one entity. The prepared PDPP3T@PSNiAA NPs exhibited high photothermal conversion efficiency (η = 34.1%) and excellent photoacoustic (PA) brightness. Meanwhile, benefiting from the photothermal effect of PDPP3T and the pH/thermal-responsive properties of PSNiAA, Dox-loaded PDPP3T@PSNiAA NPs (PDPP3T@PSNiAA-Dox NPs) were able to controllably regulate the release of Dox by pH/NIR light, in which the enhanced drug release at acidic condition upon NIR irradiation phenomenon would minimize unnecessary drug release in normal tissues and was highly beneficial for precise synergistic chemo- and photothermal therapy. |
| Databáze: | OpenAIRE |
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