Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine
| Autor: | Derya Uluduz, Feyza Erenler, Sabahattin Saip, Zeynep Oşar Siva, Baki Göksan, Huriye Balci, Aksel Siva, Ugur Uygunoglu, Fatma Ela Keskin |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Migraine Disorders 030209 endocrinology & metabolism Carbohydrate metabolism 03 medical and health sciences 0302 clinical medicine Insulin resistance Chronic Migraine Glucagon-Like Peptide 1 Internal medicine medicine Humans Insulin Neuropeptide Y business.industry General Medicine medicine.disease Neuropeptide Y receptor Glucagon-like peptide-1 Cross-Sectional Studies Glucose Endocrinology Migraine Hypothalamus Chronic Disease Female Neurology (clinical) Insulin Resistance Metabolic syndrome business 030217 neurology & neurosurgery |
| Zdroj: | Cephalalgia. 38:1773-1781 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1177/0333102417748928 |
| Popis: | Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic β-cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals. We studied the relationship of fasting neuropeptide Y with insulin resistance, β-cell function, and glucagon-like peptide-1 secretion in non-obese female chronic migraine patients. We also aimed to investigate glucose-stimulated insulin and glucagon-like peptide-1 secretions as early pathogenetic mechanisms responsible for the development of carbohydrate intolerance. Methods In this cross-sectional controlled study, 83 non-obese female migraine patients of reproductive age categorized as having episodic migraine or chronic migraine were included. The control group consisted of 36 healthy females. We studied glucose-stimulated insulin and glucagon-like peptide-1 secretion during a 75 g oral glucose tolerance test. We investigated the relationship of neuropeptide Y levels with insulin resistance and β-cell insulin secretion functions. Results Fasting glucose levels were significantly higher in migraine patients. Plasma glucose and insulin levels during the oral glucose tolerance test were otherwise similar in chronic migraine, episodic migraine and controls. Patients with chronic migraine were more insulin resistant than episodic migraine or controls ( p = 0.048). Glucagon-like peptide-1 levels both at fasting and two hours after glucose intake were similar in chronic migraine, episodic migraine, and controls. Neuropeptide Y levels were higher in migraineurs. In chronic migraine, neuropeptide Y was positively correlated with fasting glucagon-like peptide-1 levels (r = 0.57, p = 0.04), but there was no correlation with insulin resistance (r = 0.49, p = 0.09) or β-cell function (r = 0.50, p = 0.07). Discussion Non-obese premenopausal female patients with chronic migraine have higher insulin resistance, but normal β-cell function is to compensate for the increased insulin demand during fasting and after glucose intake. Increased fasting neuropeptide Y levels in migraine may be a factor leading to increased insulin resistance by specific alterations in energy intake and activation of the sympathoadrenal system. |
| Databáze: | OpenAIRE |
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