Etiological factors in primary hepatic B-cell lymphoma
| Autor: | Kanta Kikuma, Satoshi Toyoshima, Tatsuo Shimogama, Yumi Oshiro, Tetsuro Soda, Yumi Honda, Naokuni Uike, Tadaaki Yokota, Seiya Momosaki, Koichi Higaki, Seiichi Okamura, Morishige Takeshita, Jiro Watanabe |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphoma B-Cell Hepacivirus Autoimmune hepatitis Pathology and Forensic Medicine Primary biliary cirrhosis immune system diseases hemic and lymphatic diseases Autoimmune disease Humans Medicine Hepatitis B e Antigens B-cell lymphoma Molecular Biology Aged Hepatitis B-Lymphocytes business.industry Malignant lymphoma Liver Neoplasms MALT lymphoma Cell Biology General Medicine Hepatitis C Hepatitis C Antibodies Middle Aged medicine.disease BCL6 Survival Analysis Lymphoma Liver HCV Original Article Female Lymphoma Large B-Cell Diffuse business |
| Zdroj: | Virchows Archiv |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-012-1199-x |
| Popis: | Sixty-four cases of malignant lymphoma involving the liver were examined. Of these, 20 cases were histologically confirmed to be primary hepatic B-cell lymphoma. Twelve of these 20 cases were diffuse large B-cell lymphoma (DLBCL) and eight cases were mucosa-associated lymphoid tissue (MALT) lymphoma. Of the 12 cases of DLBCL, six were immunohistologically positive for CD10 and/or Bcl6 (indicating a germinal center phenotype), six were positive for Bcl2, and five were positive for CD25. Eight of the 12 DLBCL cases (66.7%) and two of the eight MALT lymphoma cases (25%) had serum anti-hepatitis C virus (HCV) antibodies and HCV RNA. The incidence of HCV infection was significantly higher in the hepatic DLBCL cases than in systemic intravascular large B-cell cases with liver involvement (one of 11 cases, 9.1%) and T/NK-cell lymphoma cases (one of 19 cases, 5.3%) (p |
| Databáze: | OpenAIRE |
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