Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

Autor:	Prescott G. Woodruff, Eric A. Hoffman, Andrew J. Hirzel, Carlos H. Martinez, Christopher B. Cooper, Deborah A. Meyers, Stephanie A. Christenson, Elizabeth E. Carretta, MeiLan K. Han, David Couper, Fernando J. Martinez, R. Graham Barr, Christine M. Freeman, Michelle Zeidler, Stephen I. Rennard, Robert Paine, Robert J. Kaner, Eugene R. Bleecker, Nadia N. Hansel, Claire M. Doerschuk, Jeffrey L. Curtis, Sara X. Li, Neil E. Alexis, Valerie R. Stolberg, Annette T. Hastie, Nirupama Putcha, Wanda K. O'Neal
Rok vydání:	2018
Předmět:	medicine.medical_specialty Sputum Cytology Pathology Immunology Pulmonary disease Gastroenterology Article Leukocyte Count Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Internal medicine Eosinophilia medicine Humans Immunology and Allergy 030212 general & internal medicine COPD Smokers business.industry Sputum Eosinophil medicine.disease Peripheral blood Respiratory Function Tests respiratory tract diseases Pulmonary Alveoli medicine.anatomical_structure 030228 respiratory system Cohort medicine.symptom business Biomarkers
Zdroj:	Journal of Allergy and Clinical Immunology. 141:429-432
ISSN:	0091-6749
Popis:	Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119e00e42d3649fae35fa4355b3306b4 https://doi.org/10.1016/j.jaci.2017.07.039 Zobrazit plný text záznamu Full Text from ScienceDirect