Organocatalytic Enantioselective Synthesis of α-Fluoro-β-amino Acid Derivatives
| Autor: | Matthew R Straub, Vladimir B. Birman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Amino acid Catalysis chemistry.chemical_compound Organic chemistry heterocyclic compounds Physical and Theoretical Chemistry Fluoroacetic acid |
| Zdroj: | Organic letters. 20(23) |
| ISSN: | 1523-7052 |
| Popis: | Asymmetric cyclocondensation of N-sulfonylimines with fluoroacetic acid promoted by isothiourea catalyst HBTM-2 generates 3-fluoro-β-lactams with high enantio- and diastereoselectivity. These reactive compounds are opened with alcohols or amines to produce the corresponding α-fluoro-β-amino acid derivatives in moderate yields. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|