Immunological Studies of the Eye Changes of Thyrotoxicosis
| Autor: | J. R. Wall, R. Odgers, B. S. Hetzel |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
viruses
medicine.medical_treatment Graves' disease Thyroid Gland Immunoglobulins Azathioprine Disease Thyroglobulin Pathogenesis Mice Adrenal Cortex Hormones Internal Medicine medicine Animals Humans Euthyroid skin and connective tissue diseases Aged Autoantibodies business.industry Stomach Thyroid Autoantibody Muscle Smooth biochemical phenomena metabolism and nutrition medicine.disease Graves Disease medicine.anatomical_structure nervous system Immunology Long-Acting Thyroid Stimulator Biological Assay Female sense organs business medicine.drug |
| Zdroj: | Australian and New Zealand Journal of Medicine. 3:162-168 |
| ISSN: | 0004-8291 |
| DOI: | 10.1111/j.1445-5994.1973.tb03970.x |
| Popis: | Summary: The relationship between plasma LATS and the ophthalmopathy of Graves' disease was studied in 122 patients including twelve with euthyroid Graves' disease. The prevalence of plasma LATS, other antibodies and increased immunoglobulin levels was correlated with the severity of the eye changes. A higher prevalence of LATS was found in patients with severe ophthalmopathy than in those with mild disease. However, there was no such relationship between the severity of the ophthalmopathy and the prevalence of other antibodies or increased immunoglobulin levels. There was an association between change in LATS levels and change in the clinical state in twelve of 17 patients studied. Worsening of ophthalmopathy was associated with rise in LATS levels in three patients while improvement was associated with fall in LATS levels in nine patients. It is concluded that immunological factors are likely to be involved in the pathogenesis of severe ophthalmopathy – LATS may be a “marker” of a more complex immunological process. For these reasons immunosuppressive therapy would appear to be worthy of continued investigation. |
| Databáze: | OpenAIRE |
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