Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation
| Autor: | Xavier Elduque, Enrique Pedroso, Anna Grandas |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Ciclització (Química)
Stereochemistry Àcids nucleics Oligonucleotides Alkyne Peptides Cyclic Catalysis Ring formation (Chemistry) Maleimides chemistry.chemical_compound Peptoids Sulfhydryl Compounds Maleimide chemistry.chemical_classification Thiol-ene reaction Cycloaddition Reaction Molecular Structure Oligonucleotide Chemistry Organic Chemistry Proteins Cyclic peptide Nucleic acids Alkynes Functional group Click chemistry Thiol Amino acids Click Chemistry Pèptids Aminoàcids Peptides Proteïnes Copper |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for conjugation with suitably derivatized nucleoside or oligonucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide-alkyne) or the same Michael-type reaction as for cyclization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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