Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives
| Autor: | Josie Chilcott, Paul Wyatt, Alison Foster, Jan Scicinski, Livermore David, Patrick M. Woollard, Michael J. Allen, Jackie E. Mordaunt |
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| Rok vydání: | 2002 |
| Předmět: |
Models
Molecular Indoles Pyrimidine Stereochemistry Clinical Biochemistry Molecular Conformation Biological Availability Pharmaceutical Science Oxytocin Biochemistry Oxytocin Antagonist Structure-Activity Relationship chemistry.chemical_compound Dogs Drug Discovery Animals Humans Moiety Benzofuran Thiazole Molecular Biology Benzofurans Indole test Organic Chemistry Antagonist Oxytocin receptor Kinetics chemistry Receptors Oxytocin Drug Design Molecular Medicine hormones hormone substitutes and hormone antagonists |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 12:1399-1404 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(02)00159-2 |
| Popis: | Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity. |
| Databáze: | OpenAIRE |
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