Peroxisome proliferator activated receptor gamma in human placenta may mediate the adverse effects of phthalates exposure in pregnancy
| Autor: | Honghui Rong, Yujing Huang, Jian Chen, Weiqun Shu, Hui Zeng, Yanzhou Wang, Lin Zhang, Hui Lin, Jose M. Garcia, Yao Tan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Peroxisome proliferator-activated receptor gamma medicine.medical_specialty endocrine system diseases medicine.drug_class Placenta Phthalic Acids Peroxisome proliferator-activated receptor Biology Toxicology 03 medical and health sciences chemistry.chemical_compound Pregnancy Internal medicine medicine Humans Progesterone chemistry.chemical_classification Estradiol Estriol Phthalate nutritional and metabolic diseases medicine.disease Fetal Blood Up-Regulation PPAR gamma 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Estrogen Cord blood Environmental Pollutants Female Hormone |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 75 |
| ISSN: | 1873-1708 |
| Popis: | Peroxisome-proliferator activated receptor gamma (PPARG) in placenta play an important role in pregnancy. Our previous study showed that it mediated the effects of phthalates on placental mRNA expression of estrogen synthetases in rats. To assess the effects of phthalate exposure on PPARG placental expression, and the contribution of PPARG to the effects of phthalates in human. 207 healthy pregnant women were recruited and their cord blood and placenta were collected upon delivery. Three phthalates, estrogens in cord blood and protein expression of PPARG in placenta were measured. Linear regression were used to analyze the relationship between phthalates exposure, PPARG expression and hormones. Phthalate levels in cord blood were positively associated with PPARG protein expression in placenta (p |
| Databáze: | OpenAIRE |
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