Hepatitis B virus occult infection in subjects with persistent isolated anti-HBc reactivity
| Autor: | Eduardo Lissen, F. Garcia de Pesquera, J.I. Jauregui, A. Castilla, Jesús Prieto, Manuel Leal, M. A. Abad, María-Pilar Civeira, Armando Sánchez-Quijano, Juan A. Pineda |
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| Rok vydání: | 1993 |
| Předmět: |
Hepatitis B virus
HBsAg Molecular Sequence Data medicine.disease_cause Polymerase Chain Reaction Asymptomatic Virus Serology Humans Medicine Hepatitis B Antibodies Base Sequence Hepatology biology medicine.diagnostic_test business.industry virus diseases Hepatitis B biology.organism_classification Hepatitis B Core Antigens Immunohistochemistry Virology digestive system diseases HBcAg Hepadnaviridae Liver biopsy Chronic Disease Immunology medicine.symptom business |
| Zdroj: | Journal of Hepatology. 17:288-293 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(05)80207-7 |
| Popis: | The aim of this study was to investigate the presence of hepatitis B virus occult infection in asymptomatic subjects with persistent anti-HBc reactivity but no other hepatitis B virus serological markers, including HBsAg, anti-HBs, IgM anti-HBc and HBV-DNA. For this purpose we used both polymerase chain reaction assays in sera and immunohistochemistry for HBsAg and HBcAg in liver biopsy specimens. Twenty-four cases were studied: 15 were drug abusers or homosexuals (eight with normal alanine aminotransferase levels) and nine were heterosexuals with raised alanine aminotransferase levels (45 U/l) but with no history of blood transfusion or ethanol intake (80 g daily). In all but five cases, liver biopsy was performed in subjects with persistent elevated alanine aminotransferase levels. In 10 out of 24 cases (41.66%) hepatitis B virus infection was demonstrated by polymerase chain reaction or immunohistochemistry, and when results from both procedures were available (n = 11) hepatitis B virus infection was detected in 63.63% of the subjects. The only clinical feature associated with HBV infection was the presence of persistent elevated alanine aminotransferase levels (p0.05). In conclusion, persistent isolated anti-HBc reactivity may be a relatively common serologic pattern for hepatitis B virus occult infection, at least in patients with chronic liver disease. |
| Databáze: | OpenAIRE |
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