The effects of recombinant human insulin-like growth factor-1/insulin-like growth factor binding protein-3 administration on lipid and carbohydrate metabolism in recreational athletes
| Autor: | Walailuck Böhning, Michael Francis, Richard I. G. Holt, Simon P. Nevitt, Nishan Guha, Dankmar Böhning, Peter Sonksen |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Carbohydrate metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Double-Blind Method Internal medicine Diabetes mellitus medicine Glucose homeostasis Humans Insulin Insulin-Like Growth Factor I medicine.diagnostic_test business.industry Cholesterol Lipid metabolism medicine.disease Lipid Metabolism Recombinant Proteins Insulin-Like Growth Factor Binding Protein 3 chemistry Athletes 030220 oncology & carcinogenesis Homeostatic model assessment Carbohydrate Metabolism Female business Lipid profile Carrier Proteins |
| Zdroj: | Clinical endocrinologyREFERENCES. 94(4) |
| ISSN: | 1365-2265 |
| Popis: | ObjectivePrevious studies suggested that recombinant human IGF-1 (rhIGF-1) administration affects carbohydrate and lipid metabolism in healthy people and in people with diabetes. This study aimed to determine the effects of rhIGF-1/rhIGF binding protein-3 (rhIGFBP-3) administration on glucose homeostasis and lipid metabolism in healthy recreational athletes.Design and SettingRandomized, double-blind, placebo-controlled rhIGF-1/rhIGFBP-3 administration study at Southampton General Hospital, UK.Participants56 recreational athletes (30 men, 26 women).MethodsParticipants were randomly assigned to receive placebo, low-dose rhIGF-1/rhIGFBP-3 (30 mg/day) or high-dose rhIGF-1/rhIGFBP-3 (60 mg/day) for 28 days. The following variables were measured before and immediately after the treatment period: fasting lipids, glucose, insulin, C-peptide and glycated haemoglobin. The homeostatic model assessment (HOMA-IR) was used to estimate insulin sensitivity and indirect calorimetry to assess substrate oxidation rates. The general linear model approach was used to compare treatment group changes with the placebo group.ResultsCompared with the placebo group, there was a significant reduction in fasting triglycerides in participants treated with high-dose rhIGF-1/rhIGFBP-3 (p = .030), but not in the low-dose group (p = .390). In women, but not in men, there were significant increases in total cholesterol (p = .003), HDL cholesterol (p = .001) and LDL cholesterol (p = .008). These lipid changes were associated with reduced fasting insulin (p = .010), C-peptide (p = .001) and HOMA-IR (p = .018) in women and reduced C-peptide (p = .046) in men.ConclusionsrhIGF-1/rhIGFBP-3 administration for 28 days reduced insulin concentration, improved insulin sensitivity and had significant effects on lipid profile including decreased fasting triglycerides. |
| Databáze: | OpenAIRE |
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