Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
| Autor: | Aleš Hejčl, Petr Vachata, Tomáš Radovnický, Petr Kelbich, Jan Procházka, Martin Sameš, Jan Špička, Inka Matuchová, Jan Lodin, Eva Hanuljaková, Jan Krejsek |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Central nervous system Inflammation CNS haemorrhage Gastroenterology General Biochemistry Genetics and Molecular Biology Article cerebrospinal fluid aspartate aminotransferase in CSF 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine Medicine In patient total protein in CSF Stage (cooking) lcsh:Science Ecology Evolution Behavior and Systematics Intracranial pressure business.industry coefficient of energy balance Paleontology Extravasation neutrophils in CSF erythrocytes in CSF inflammation in CNS 030104 developmental biology medicine.anatomical_structure Space and Planetary Science Mann–Whitney U test lcsh:Q medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Life, Vol 11, Iss 300, p 300 (2021) Life Volume 11 Issue 4 |
| ISSN: | 2075-1729 |
| Popis: | Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage. We compared 109 survivors (Glasgow Outcome Score (GOS) 5-3) and 30 patients with poor outcomes (GOS 2-1). Statistical evaluations were performed using the Wilcoxon signed-rank test and the Mann–Whitney U test. Almost the same numbers of erythrocytes in both subgroups appeared in days 0–3 (p = 0.927) and a significant increase in patients with GOS 2-1 in days 7–10 after the hemorrhage (p = 0.004) revealed persistence of extravascular blood in the CNS as an adverse factor. We assess 43.3% of patients with GOS 2-1 and only 27.5% of patients with GOS 5-3 with low values of the coefficient of energy balance (KEB < 15.0) in days 0–3 after the hemorrhage as a trend to immediate intensive inflammation in the CNS of patients with poor outcomes. We consider significantly higher concentration of total protein of patients with GOS 2-1 in days 0–3 after hemorrhage (p = 0.008) as the evidence of immediate simultaneously manifested intensive inflammation, swelling of the brain and elevation of intracranial pressure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|