A meta-analysis of neurodevelopmental outcomes at 4-10 years in children born at 22-25 weeks gestation
| Autor: | Sharon Ding, Thierry Daboval, Gregory P Moore, Brigitte Lemyre, Nick Barrowman |
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| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Gestational Age 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Medicine Humans 030212 general & internal medicine Child business.industry Infant Newborn Gestational age General Medicine Random effects model Child development Neurodevelopmental Disorders Meta-analysis Child Preschool Infant Extremely Premature Pediatrics Perinatology and Child Health Cohort Gestation Absolute Change business Developed country |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 108(7) |
| ISSN: | 1651-2227 |
| Popis: | AIM To update our meta-analysis on neurodevelopmental disability rates in children born at 22-25 weeks gestation. The main outcome measure was rates of neurodevelopmental disability in survivors at age 4-10 years. METHODS We used a peer-reviewed electronic and grey search to identify articles. Two authors independently reviewed cohorts published after May 2012 with: born ≥1995 in a developed nation; assessed at 4-10 years; prospective; >65% follow-up; definitions for neurodevelopmental disability as per the EPICure cohort; results reported by gestation. We contacted authors for clarification. Random effects meta-analysis was used to estimate pooled proportions of neurodevelopmental disability. Within each study, the absolute change in proportions with each week was estimated and then pooled. RESULTS We reviewed 3980 records; 21 articles were assessed and six were included. With the previous 9 cohorts, the meta-analysis now contains 15. Rates of moderate-to-severe neurodevelopmental disability were as follows: 42% (95% CI 23,64%; I2 0%) at 22; 41% (95% CI 31,52%; I2 20%) at 23; 32% (95% CI 25,39%; I2 45%) at 24; 23% (95% CI 18,29%; I2 60%) at 25 weeks. The analysis shows a significant decrease in risk of moderate-to-severe neurodevelopmental disability between each week (8.1% (95% CI -11.8, -4.5%); I2 0%; p |
| Databáze: | OpenAIRE |
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