Bile acid metabolism in cirrhotic liver tissue — altered synthesis and impaired hepatic secretion
| Autor: | Jiro Yanagisawa, Hiroshi Miyazaki, Yoshio Akashi, Fumio Nakayama |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhotic liver Cirrhosis medicine.drug_class Clinical Biochemistry Cholic Acid Chenodeoxycholic Acid digestive system Biochemistry Gastroenterology Bile Acids and Salts chemistry.chemical_compound Chenodeoxycholic acid Liver tissue Internal medicine medicine Humans Secretion Bile acid Biochemistry (medical) Cholic Acids General Medicine Metabolism Middle Aged medicine.disease Endocrinology Liver chemistry Bile acid metabolism Female |
| Zdroj: | Clinica Chimica Acta. 168:199-206 |
| ISSN: | 0009-8981 |
| Popis: | Bile acid analysis of mild and severe cirrhotic liver showed that with the advancement of cirrhosis the concentration of chenodeoxycholic acid in liver tissue becomes higher, resulting in the lower ratio of cholic to chenodeoxycholic acid probably due to the progressive alteration of cholic and chenodeoxycholic acid synthesis with the advancement of liver cirrhosis. Bile acid analysis of paired liver and bile of severe cirrhosis showed that the ratio of cholic to chenodeoxycholic acid in liver was lower than that in bile or even with that in bile. This can be explained by postulating the impaired hepatic secretion of bile acids, especially chenodeoxycholic acid. The impaired secretion together with the relatively well preserved chenodeoxycholic acid synthesis results in the accumulation of chenodeoxycholic acid in liver tissue with cirrhosis. |
| Databáze: | OpenAIRE |
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