In Vivo Spectrophotometric Evaluation of Normal, Lesional, and Laser-Treated Skin in Patients with Port-Wine Stains
| Autor: | Irving Itzkan, Donna B.C. Bourgelais, Barbara A. Gilchrest, Kenneth A. Arndt, Joel M. Noe, Stephen V. Tang |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Aging medicine.medical_specialty Skin Neoplasms Adolescent Port wine Dermatologic Surgical Procedures Color Color shift Dermatology Absorption (skin) Biochemistry law.invention Lesion Hemoglobins Older patients law In vivo Ophthalmology medicine Humans In patient Molecular Biology Skin business.industry Cell Biology Middle Aged Laser Surgery Spectrophotometry Laser Therapy medicine.symptom Hemangioma business |
| Zdroj: | Journal of Investigative Dermatology. 80:420-423 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12555459 |
| Popis: | The influence of patient age and argon laser therapy on port-wine stains (PWS) was studied quantitatively in 16 patients aged 15-64 years using a spectrophotometer and computer graphics/statistics program. Normalized reflectance curves revealed a 10-20% decrease with age in the reflectance of normal skin from 400 nm to 650 nm, with an even more pronounced reflectance decrease in the region of peak deoxyhemoglobin absorption at approximately 555 nm. In each patient, PWS reflectance was less than that in the normal skin, as expected, and the average discrepancy increased with age from approximately 25% to 50%, with further reduction at 555 nm. The data suggest that with advancing age, both normal skin and PWS have a greater total hemoglobin content and an increased proportion of deoxyhemoglobin, consistent with increasing vascular dilation and tortuosity; and that the age-associated changes in PWS are an exaggeration of those in normal skin. Laser-treated PWS in both young and old patients had reflectance curves indistinguishable from those of untreated PWS in young patients. This implies, contrary to published clinical impressions, that in the absence of scarring the results of argon laser therapy are the same in young and old patients, but that only older patients experience a significant color shift in the lesion. |
| Databáze: | OpenAIRE |
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