FOXO1 overexpression is correlated with poor prognosis in epithelial ovarian cancer
| Autor: | Zhongqiu Lin, Longyang Liu, Zhaoyang Zeng, Juanjuan Yi, Jianhuan Yuan, Yingxia Ning, Tingting Yao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Intestinal metastasis endocrine system Cancer Research medicine.medical_specialty Poor prognosis endocrine system diseases FOXO1 Carcinoma Ovarian Epithelial Disease-Free Survival Metastasis Internal medicine Biomarkers Tumor Genetics medicine Humans 0501 psychology and cognitive sciences Epithelial ovarian cancer Target therapy Stage (cooking) 0505 law Forkhead Box Protein O1 business.industry 05 social sciences food and beverages General Medicine Middle Aged Prognosis medicine.disease female genital diseases and pregnancy complications 050501 criminology Immunohistochemistry Female business hormones hormone substitutes and hormone antagonists 050104 developmental & child psychology |
| Zdroj: | Cancer Biomarkers. 28:1-8 |
| ISSN: | 1875-8592 1574-0153 |
| DOI: | 10.3233/cbm-182119 |
| Popis: | Objective To investigate FOXO1 expression in epithelial ovarian cancer (EOC), and to explore its correlation with clinicopathological parameters and prognosis of EOC. Methods Two hundred and sixteen cases of paraffin-embedded EOC and 41 paratumor tissues from 2009 to 2017 that had been pathologically confirmed at the memorial hospital of Sun Yat-sen University were included in this study, and the expression of FOXO1 was performed by immunohistochemistry using a polyclonal antibody specific for FOXO1. Results FOXO1 protein expression is associated with Recurrence free and overall survival in EOC patients; In addition, FOXO1 expression is associated with age, FIGO stage, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence and differentiation grade; Moreover, in a multivariate model FOXO1 overexpression was an independent predictor of poor survival in EOC. Conclusion FOXO1 may play a candidate oncogenic role in EOC, and FOXO1 is a useful independent prognostic marker in EOC, and it may provide a candidate target therapy in future. |
| Databáze: | OpenAIRE |
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