Instrumentation for electrochemical performance characterization of neural electrodes
| Autor: | Malcom B. McIntosh, Michael P. Marsh, Renae M. Forsman, Christopher J. Kimble, Kevin E. Bennet, Seth A. Hara, Terry L. Reed, Kendall H. Lee, James N. Kruchowski, Jonathan R. Tomshine |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Instrumentation 010401 analytical chemistry Peristaltic pump Electrolyte 01 natural sciences 0104 chemical sciences 03 medical and health sciences ARTICLES 0302 clinical medicine Electrode Waveform Voltammetry Sensitivity (electronics) 030217 neurology & neurosurgery Voltage Biomedical engineering |
| Popis: | In an effort to determine the chronic stability, sensitivity, and thus the potential viability of various neurochemical recording electrode designs and compositions, we have developed a custom device called the Voltammetry Instrument for Neurochemical Applications (VINA). Here, we describe the design of the VINA and initial testing of its functionality for prototype neurochemical sensing electrodes. The VINA consists of multiple electrode fixtures, a flowing electrolyte bath, associated reservoirs, peristaltic pump, voltage waveform generator, data acquisition hardware, and system software written in National Instrument’s LabVIEW. The operation of VINA was demonstrated on a set of boron-doped diamond neurochemical recording electrodes, which were subjected to an applied waveform for a period of eighteen days. Each electrode’s cyclic voltammograms (CVs) were recorded, and sensitivity calibration to dopamine (DA) was performed. Results showed an initial decline with subsequent stabilization in the CV current measured during the voltammetric sweep, corresponding closely with changes in electrode sensitivity to DA. The VINA has demonstrated itself as a useful tool for the characterization of electrode stability and chronic electrochemical performance. |
| Databáze: | OpenAIRE |
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