Sex difference in sensitization to the locomotor effects of mazindol in rats
| Autor: | Reinaldo N. Takahashi, Marlene Zanin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Motor Activity Anorectic drug Locomotor activity Open field Dopamine Internal medicine Animal activity medicine Animals Rats Wistar Sensitization Sex Characteristics Mazindol General Neuroscience Stimulation Chemical Rats Endocrinology medicine.anatomical_structure Female Psychology Injections Intraperitoneal Antidiuretic medicine.drug |
| Zdroj: | Brain Research Bulletin. 34:385-387 |
| ISSN: | 0361-9230 |
| Popis: | Male and female rats were treated daily for 7 days with mazindol (5, 10, and 20 mg/kg), an anorectic drug, and tested in the open field. Mazindol developed sensitization to its locomotor stimulatory effect in both sexes on day 7 with a nondose-dependent pattern of response. However, the locomotor activity appeared to be sex dependent, female rats being more sensitive. Following a challenge dose of mazindol (10 and 20 mg/kg) on day 10, a marked enhancement of locomotion was seen in female rats. These findings indicate that repeated administration of mazindol produces sex-dependent sensitization to its effect on locomotor behavior. |
| Databáze: | OpenAIRE |
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