Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance
| Autor: | Monika Fleshner, Claude Gronfier, Christopher A. DeSouza, Charles A. Czeisler, Kenneth P. Wright, Amanda L. Drake, Danielle J. Frey |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Immunology Circadian clock Article Melatonin Behavioral Neuroscience Young Adult Stress Physiological Internal medicine medicine Humans Circadian rhythm biology Endocrine and Autonomic Systems business.industry Tumor Necrosis Factor-alpha C-reactive protein Area under the curve Circadian Rhythm Interleukin-10 Sleep deprivation Endocrinology C-Reactive Protein biology.protein Sleep Deprivation Female medicine.symptom Entrainment (chronobiology) business Biomarkers medicine.drug |
| Zdroj: | Brain, behavior, and immunity. 47 |
| ISSN: | 1090-2139 |
| Popis: | Cortisol and inflammatory proteins are released into the blood in response to stressors and chronic elevations of blood cortisol and inflammatory proteins may contribute to ongoing disease processes and could be useful biomarkers of disease. How chronic circadian misalignment influences cortisol and inflammatory proteins, however, is largely unknown and this was the focus of the current study. Specifically, we examined the influence of weeks of chronic circadian misalignment on cortisol, stress ratings, and pro- and anti- inflammatory proteins in humans. We also compared the effects of acute total sleep deprivation and chronic circadian misalignment on cortisol levels. Healthy, drug free females and males (N=17) aged 20-41 participated. After three weeks of maintaining consistent sleep-wake schedules at home, six laboratory baseline days and nights, a 40-h constant routine (CR, total sleep deprivation) to examine circadian rhythms for melatonin and cortisol, participants were scheduled to a 25-day laboratory entrainment protocol that resulted in sleep and circadian disruption for eight of the participants. A second constant routine was conducted to reassess melatonin and cortisol rhythms on days 34-35. Plasma cortisol levels were also measured during sampling windows every week and trapezoidal area under the curve (AUC) was used to estimate 24-h cortisol levels. Inflammatory proteins were assessed at baseline and near the end of the entrainment protocol. Acute total sleep deprivation significantly increased cortisol levels (p |
| Databáze: | OpenAIRE |
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