Sex hormones in the modulation of irritable bowel syndrome

Autor: Agata Mulak, Yvette Tache, Muriel H. Larauche
Rok vydání: 2014
Předmět:
Male
Pituitary-Adrenal System
Physiology
Comorbidity
Gut flora
Oral and gastrointestinal
Irritable Bowel Syndrome
Sex hormone-binding globulin
Intestinal mucosa
Risk Factors
Prevalence
2.1 Biological and endogenous factors
Sex hormones
Brain-gut axis
Aetiology
Intestinal Mucosa
Gonadal Steroid Hormones
Irritable bowel syndrome
media_common
biology
Microbiota
Pain Research
Gastroenterology
Chronic pain
General Medicine
Prognosis
Intestines
Mental Health
Female
Chronic Pain
Signal Transduction
Hypothalamo-Hypophyseal System
medicine.drug_class
media_common.quotation_subject
Clinical Sciences
Autonomic Nervous System
Pain modulation
Sex Factors
Behavioral and Social Science
medicine
Animals
Humans
Menstrual Cycle
Menstrual cycle
Gastroenterology & Hepatology
Contraception/Reproduction
Neurosciences
biology.organism_classification
medicine.disease
Estrogen
Brain Disorders
Immunology
biology.protein
Digestive Diseases
Hormone
Zdroj: World journal of gastroenterology, vol 20, iss 10
ISSN: 1007-9327
DOI: 10.3748/wjg.v20.i10.2433
Popis: Compelling evidence indicates sex and gender differences in epidemiology, symptomatology, pathophysiology, and treatment outcome in irritable bowel syndrome (IBS). Based on the female predominance as well as the correlation between IBS symptoms and hormonal status, several models have been proposed to examine the role of sex hormones in gastrointestinal (GI) function including differences in GI symptoms expression in distinct phases of the menstrual cycle, in pre- and post-menopausal women, during pregnancy, hormonal treatment or after oophorectomy. Sex hormones may influence peripheral and central regulatory mechanisms of the brain-gut axis involved in the pathophysiology of IBS contributing to the alterations in visceral sensitivity, motility, intestinal barrier function, and immune activation of intestinal mucosa. Sex differences in stress response of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, neuroimmune interactions triggered by stress, as well as estrogen interactions with serotonin and corticotropin-releasing factor signaling systems are being increasingly recognized. A concept of "microgenderome" related to the potential role of sex hormone modulation of the gut microbiota is also emerging. Significant differences between IBS female and male patients regarding symptomatology and comorbidity with other chronic pain syndromes and psychiatric disorders, together with differences in efficacy of serotonergic medications in IBS patients confirm the necessity for more sex-tailored therapeutic approach in this disorder.
Databáze: OpenAIRE
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