Altered behavior and neural activity in conspecific cagemates co-housed with mouse models of brain disorders
| Autor: | Sang Kun Lee, Jung-Seok Yoo, Arshi Khalid, Soyun Kim, Seungmoon Jung, Daejong Jeon, Soon-Tae Lee, Hyunwoo Yang, Keun-Hwa Jung, Kon Chu, Ji Hyun Park, Jangsup Moon, Jin Soo Seo |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Patch-Clamp Techniques Experimental and Cognitive Psychology Anxiety Muscarinic Agonists Membrane Potentials Developmental psychology Mice 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine medicine Animals Interpersonal Relations Maze Learning Prefrontal cortex Swimming Social stress Analysis of Variance Electroshock Depression Aggression Pilocarpine Brain medicine.disease Mental health Social relation Mice Inbred C57BL 030104 developmental biology Epilepsy Temporal Lobe Hindlimb Suspension Exploratory Behavior medicine.symptom Psychology Psychosocial Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Physiology & Behavior. 163:167-176 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2016.05.031 |
| Popis: | The psychosocial environment is one of the major contributors of social stress. Family members or caregivers who consistently communicate with individuals with brain disorders are considered at risk for physical and mental health deterioration, possibly leading to mental disorders. However, the underlying neural mechanisms of this phenomenon remain poorly understood. To address this, we developed a social stress paradigm in which a mouse model of epilepsy or depression was housed long-term (>4weeks) with normal conspecifics. We characterized the behavioral phenotypes and electrophysiologically investigated the neural activity of conspecific cagemate mice. The cagemates exhibited deficits in behavioral tasks assessing anxiety, locomotion, learning/memory, and depression-like behavior. Furthermore, they showed severe social impairment in social behavioral tasks involving social interaction or aggression. Strikingly, behavioral dysfunction remained in the cagemates 4weeks following co-housing cessation with the mouse models. In an electrophysiological study, the cagemates showed an increased number of spikes in medial prefrontal cortex (mPFC) neurons. Our results demonstrate that conspecifics co-housed with mouse models of brain disorders develop chronic behavioral dysfunctions, and suggest a possible association between abnormal mPFC neural activity and their behavioral pathogenesis. These findings contribute to the understanding of the psychosocial and psychiatric symptoms frequently present in families or caregivers of patients with brain disorders. |
| Databáze: | OpenAIRE |
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