Characterization of Fractalkine in Rat Brain Cells: Migratory and Activation Signals for CX3CR-1-Expressing Microglia
| Autor: | D, Maciejewski-Lenoir, S, Chen, L, Feng, R, Maki, K B, Bacon |
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| Rok vydání: | 1999 |
| Předmět: |
Receptors
CXCR3 Immunology MAP Kinase Kinase 1 Protein Serine-Threonine Kinases Rats Sprague-Dawley Cell Movement Proto-Oncogene Proteins Animals Immunology and Allergy Calcium Signaling RNA Messenger Cell Size Brain Chemistry Mitogen-Activated Protein Kinase Kinases Cell Death Chemokine CX3CL1 Brain Membrane Proteins Protein-Tyrosine Kinases Actins Chemokines CX3C Rats Astrocytes Receptors Chemokine Microglia Chemokines CXC Proto-Oncogene Proteins c-akt Cell Division Signal Transduction |
| Zdroj: | The Journal of Immunology. 163:1628-1635 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization: fractalkine is expressed constitutively in neurons and is up-regulated by TNF-α and IL-1β in astrocytes. Expression of its specific receptor, CX3C-R1, is restricted to astrocytes and microglia. We have analyzed the functional correlates of this expression and demonstrate that fractalkine induces microglial cell migration and activation. However, the activity of this chemokine on astrocytes may also be highly relevant in inducing astrocyte-microglia cell interactions through cytokine/mediator release leading to microglial activation. |
| Databáze: | OpenAIRE |
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