Effect of left ventricular function on diagnostic accuracy of FDG SPECT

Autor: Norihisa Tonami, Sugako Kanayama, Tatsuya Yoneyama, Jeroen J. Bax, Kinichi Hisada, Frans C. Visser, Paul K. Blanksma, Stephan G. Nekolla, Ichiro Matsunari
Přispěvatelé: Faculteit Medische Wetenschappen/UMCG
Rok vydání: 2006
Předmět:
Male
medicine.medical_specialty
TC-99M-SESTAMIBI
medicine.medical_treatment
Myocardial Infarction
EMISSION COMPUTED-TOMOGRAPHY
Diagnostic accuracy
Revascularization
Sensitivity and Specificity
Severity of Illness Index
F-18-FDG
ACQUISITION SPECT
Ventricular Dysfunction
Left
Fluorodeoxyglucose F18
PERFUSION
Medicine
FLUORINE-18-FDG SPECT
Humans
Radiology
Nuclear Medicine and imaging
In patient
cardiovascular diseases
neoplasms
Fluorodeoxyglucose
Tomography
Emission-Computed
Single-Photon
medicine.diagnostic_test
Ventricular function
business.industry
Reproducibility of Results
Stroke Volume
General Medicine
Pet imaging
Middle Aged
DYSFUNCTION
carbohydrates (lipids)
PET
SINGLE
MYOCARDIAL VIABILITY
SPECT
Positron-Emission Tomography
cardiovascular system
REVASCULARIZATION
Female
Radiology
Radiopharmaceuticals
business
Nuclear medicine
Perfusion
Emission computed tomography
medicine.drug
Zdroj: ANNALS OF NUCLEAR MEDICINE, 20(1), 51-56. SPRINGER
ISSN: 0914-7187
Popis: Objectives: Fluorine-18 fluorodeoxyglucose (FDG) SPECT has emerged as an alternative to dedicated PET imaging. However, it remains uncertain whether FDG SPECT is an as accurate for viability assessment as FDG PET in patients with severely reduced left ventricular function. The aim of the study was to assess the diagnostic accuracy of FDG SPECT in a head-to-head comparison with FDG PET, and divide the patients according to the severity of left ventricular dysfunction. Methods: A total of 47 patients, with a history of myocardial infarction underwent FDG/perfusion (Tc-99m-sestamibi or Tl-201) SPECT as well as FDG/N-13-ammonia PET. The patients were divided into 2 subgroups based on the left ventricular ejection fraction (LVEF) (35% cutoff). The left ventricular myocardium was divided into 13 segments, and each segment was classified as viable or scar using a semi-quantitative scoring system based on defect severity and the presence or absence of perfusion-FDG mismatch. Results: Of the 47 patients studied, 23 had LVEF = 35% (high LVEF group; mean 47 +/- 6%). In the low LVEF group, 213 segments (71%) were dysfunctional, as compared to 102 (33%) in the high LVEF group. The agreement for detection of viability between PET and SPECT in the low LVEF group was 82% (kappa 0.63), which was not different from the agreement in the high LVEF group (85%, kappa 0.66, p = 0.42 versus low LVEF group). Conclusions: The results indicate that FDG SPECT can be used for tissue viability assessment regardless of the severity of left ventricular dysfunction.
Databáze: OpenAIRE
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