Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study

Autor: Anastasia Xourafa, Rosario Rapisarda, Luca Zanoli, Agostino Gaudio, Pietro Castellino, Salvatore Santo Signorelli, Antonino Catalano
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Osteoporosis
Population
lcsh:Medicine
030204 cardiovascular system & hematology
Predictive markers
Carotid Intima-Media Thickness
Article
03 medical and health sciences
0302 clinical medicine
Absorptiometry
Photon
Internal medicine
Outpatients
medicine
Humans
030212 general & internal medicine
cardiovascular diseases
education
Inverse correlation
lcsh:Science
Pulse wave velocity
Femoral neck
Aged
education.field_of_study
Multidisciplinary
business.industry
Femur Neck
lcsh:R
atherosclerosis
elderly
pulse wave velocity
arterial stiffness
postmenopause
bone mineral density
Hemodynamics
Endocrine system and metabolic diseases
Middle Aged
medicine.disease
Cardiovascular biology
Vascular ageing
medicine.anatomical_structure
Carotid-Femoral Pulse Wave Velocity
Arterial stiffness
cardiovascular system
Female
lcsh:Q
Densitometry
business
Biomarkers
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
ISSN: 2045-2322
Popis: Osteoporosis and atherosclerosis are significant public health problems that often coexist, especially in the elderly. Although some studies have reported an age-dependent relationship, others have suggested a causal relationship between osteoporosis and atherosclerosis. The aim of our study was to evaluate the cardiovascular risk in a population of patients with osteoporosis by measuring carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cf-PWV). A total of 58 patients with osteoporosis and an equal number of healthy control subjects were enrolled. All subjects underwent (1) a bone densitometry examination using dual X-ray absorptiometry, (2) a vascular evaluation for the measurements of cIMT and cf-PWV and (3) a blood sample for the evaluation of lipids and phosphocalcic metabolism. Patients with osteoporosis had a significant increase in cIMT and cf-PWV. There was also a significant inverse correlation between the femoral neck BMD and cf-PWV values. In conclusion, osteoporotic outpatients have earlier vascular ageing, with an increase of arterial stiffness. These data support a possible association between osteoporosis and atherosclerosis independent of age.
Databáze: OpenAIRE
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