Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study
Autor: | Anastasia Xourafa, Rosario Rapisarda, Luca Zanoli, Agostino Gaudio, Pietro Castellino, Salvatore Santo Signorelli, Antonino Catalano |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty Osteoporosis Population lcsh:Medicine 030204 cardiovascular system & hematology Predictive markers Carotid Intima-Media Thickness Article 03 medical and health sciences 0302 clinical medicine Absorptiometry Photon Internal medicine Outpatients medicine Humans 030212 general & internal medicine cardiovascular diseases education Inverse correlation lcsh:Science Pulse wave velocity Femoral neck Aged education.field_of_study Multidisciplinary business.industry Femur Neck lcsh:R atherosclerosis elderly pulse wave velocity arterial stiffness postmenopause bone mineral density Hemodynamics Endocrine system and metabolic diseases Middle Aged medicine.disease Cardiovascular biology Vascular ageing medicine.anatomical_structure Carotid-Femoral Pulse Wave Velocity Arterial stiffness cardiovascular system Female lcsh:Q Densitometry business Biomarkers |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Osteoporosis and atherosclerosis are significant public health problems that often coexist, especially in the elderly. Although some studies have reported an age-dependent relationship, others have suggested a causal relationship between osteoporosis and atherosclerosis. The aim of our study was to evaluate the cardiovascular risk in a population of patients with osteoporosis by measuring carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cf-PWV). A total of 58 patients with osteoporosis and an equal number of healthy control subjects were enrolled. All subjects underwent (1) a bone densitometry examination using dual X-ray absorptiometry, (2) a vascular evaluation for the measurements of cIMT and cf-PWV and (3) a blood sample for the evaluation of lipids and phosphocalcic metabolism. Patients with osteoporosis had a significant increase in cIMT and cf-PWV. There was also a significant inverse correlation between the femoral neck BMD and cf-PWV values. In conclusion, osteoporotic outpatients have earlier vascular ageing, with an increase of arterial stiffness. These data support a possible association between osteoporosis and atherosclerosis independent of age. |
Databáze: | OpenAIRE |
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