In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide
| Autor: | Véronique Quemener, Jacques-Philippe Moulinoux, B. Cipolla, Y. Blanchard, L Chamaillard, F. Guille, R. Havouis |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Eflornithine Lung Neoplasms Cyclophosphamide Urology medicine.medical_treatment Antineoplastic Agents Adenocarcinoma Pharmacology Biology chemistry.chemical_compound In vivo Metronidazole Antineoplastic Combined Chemotherapy Protocols Polyamines Putrescine medicine Animals Antineoplastic Agents Alkylating Protein Synthesis Inhibitors Oxidoreductases Acting on CH-NH Group Donors Chemotherapy Dose-Response Relationship Drug Prostatic Neoplasms Drug Synergism Neomycin Rats Inbred Strains Rats Survival Rate chemistry Vindesine Drug Therapy Combination Methotrexate Polyamine Polyamine oxidase medicine.drug |
| Zdroj: | Urological Research. 24:93-99 |
| ISSN: | 1434-0879 0300-5623 |
| Popis: | Polyamine deprivation in vivo produces significant tumor growth inhibition of the hormone-resistant, metastatic Dunning Mat-LyLu murine prostatic carcinoma. In order to produce a cytotoxic effect in addition to the cytostatic effect of polyamine deprivation, various chemotherapy regimens, combined with drug-containing polyamine-deficient chow (DC-PDC), were assessed. Triple chemotherapy combining methotrexate, cyclophosphamide and vindesine; and monochemotherapy with high-dose cyclophosphamide (90 mg. kg-1) and low-dose cyclophosphamide (20 mg.kg-1) were studied alone and in combination with DC-PDC. A variant of DC-PDC excluding the polyamine oxidase inhibitor MDL 72527 was also studied in combination with low-dose cyclophosphamide. The triple-chemotherapy regimen alone or in combination with polyamine deprivation was effective on tumor growth inhibition but was also toxic. High-dose cyclophosphamide alone produced significant tumor growth inhibition and an increase in life span. High-dose cyclophosphamide in combination with DC-PDC was also effective on tumor growth but was also toxic. Low-dose cyclophosphamide alone was moderately effective on tumor growth inhibition with a marginal increase in life span. When combined with polyamine deprivation, results with low-dose cyclophosphamide compared favourably with those of high-dose cyclophosphamide alone and prevented the formation of lung metastases. The polyamine oxidase inhibitor does not appear to be mandatory to achieve this effect if DC-PDC is combined with low-dose cyclophosphamide. Polyamine deprivation appears to be an important tool in anticancer therapy, allowing the use of reduced doses of cytotoxic agents with the same antitumoral efficacy. |
| Databáze: | OpenAIRE |
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