Photoacoustic Impulse Response of Lipid-Coated Ultrasound Contrast Agents
| Autor: | Jordan S. Lum, Marco A. Inzunza-Ibarra, Todd W. Murray, Mark A. Borden, Verya Daeichin |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Acoustics and Ultrasonics media_common.quotation_subject Contrast Media 01 natural sciences Article law.invention law Nondestructive testing 0103 physical sciences Contrast (vision) Electrical and Electronic Engineering 010301 acoustics Instrumentation Impulse response Ultrasonography media_common Laser ultrasonics Microbubbles business.industry Ultrasound Acoustics Laser Lipids Transducer business Biomedical engineering |
| Zdroj: | IEEE Trans Ultrason Ferroelectr Freq Control |
| ISSN: | 1525-8955 0885-3010 |
| Popis: | The utility of ultrasound imaging and therapy with microbubbles may be greatly enhanced by determining their impulse-response dynamics as a function of size and composition. Prior methods for microbubble characterization utilizing high-speed cameras, acoustic transducers and laser-based techniques typically scan a limited frequency range. Here, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics. |
| Databáze: | OpenAIRE |
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