Stress Reduction in the Secondary Prevention of Cardiovascular Disease
| Autor: | Maxwell Rainforth, Robert H. Schneider, Jane Morley Kotchen, Sanford Nidich, Clarence E. Grim, Charles N. Alexander, Carolyn Gaylord-King, John W. Salerno, Theodore A. Kotchen |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Health Knowledge Attitudes Practice medicine.medical_specialty Time Factors Myocardial Infarction Coronary Disease Kaplan-Meier Estimate Disease Transcendental meditation Risk Assessment Article law.invention Wisconsin Patient Education as Topic Randomized controlled trial Risk Factors law Internal medicine Secondary Prevention medicine Clinical endpoint Humans Myocardial infarction Stroke Aged Proportional Hazards Models business.industry Hazard ratio Middle Aged medicine.disease Black or African American Hospitalization Meditation Treatment Outcome Blood pressure Multivariate Analysis Physical therapy Female Cardiology and Cardiovascular Medicine business Stress Psychological |
| Zdroj: | Circ Cardiovasc Qual Outcomes |
| ISSN: | 1941-7705 1941-7713 |
| Popis: | Background— Blacks have disproportionately high rates of cardiovascular disease. Psychosocial stress may contribute to this disparity. Previous trials on stress reduction with the Transcendental Meditation (TM) program have reported improvements in cardiovascular disease risk factors, surrogate end points, and mortality in blacks and other populations. Methods and Results— This was a randomized, controlled trial of 201 black men and women with coronary heart disease who were randomized to the TM program or health education. The primary end point was the composite of all-cause mortality, myocardial infarction, or stroke. Secondary end points included the composite of cardiovascular mortality, revascularizations, and cardiovascular hospitalizations; blood pressure; psychosocial stress factors; and lifestyle behaviors. During an average follow-up of 5.4 years, there was a 48% risk reduction in the primary end point in the TM group (hazard ratio, 0.52; 95% confidence interval, 0.29–0.92; P =0.025). The TM group also showed a 24% risk reduction in the secondary end point (hazard ratio, 0.76; 95% confidence interval, 0.51–0.1.13; P =0.17). There were reductions of 4.9 mmHg in systolic blood pressure (95% confidence interval −8.3 to –1.5 mmHg; P =0.01) and anger expression ( P Conclusions— A selected mind–body intervention, the TM program, significantly reduced risk for mortality, myocardial infarction, and stroke in coronary heart disease patients. These changes were associated with lower blood pressure and psychosocial stress factors. Therefore, this practice may be clinically useful in the secondary prevention of cardiovascular disease. Clinical Trial Registration— URL: www.clinicaltrials.gov Unique identifier: NCT01299935. |
| Databáze: | OpenAIRE |
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