The role of heparin in preventing the early silent ischemia in carotid stenting
| Autor: | Dilara Mermi Dibek, Onur Ergun, Mehmet Fevzi Oztekin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Brain Ischemia 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Carotid Stenosis cardiovascular diseases Heparin business.industry General Neuroscience General Medicine equipment and supplies Silent ischemia Diffusion Magnetic Resonance Imaging Treatment Outcome surgical procedures operative 030104 developmental biology cardiovascular system Cardiology Stents Carotid stenting Complication business 030217 neurology & neurosurgery medicine.drug |
| Popis: | Serebral silent ischemia is a complication of carotid stenting. If silent ischemia occurs 24 h later of carotid stenting, it called early serebral silent ischemia. The aim of this study was to evaluate the effect of heparin infusion on the prevention of early silent ischemia in patients who underwent carotid stenting.We included 26 patients who underwent carotid stenting. Patients who had carotid stenting, we randomized into two groups. The first group of patients were given continuously heparin infusion a maximum of 20,000 units for 24 h, and screened the aPTT value each 6 h. The aPTT value aimed a range of 2-3 times to up baseline. The second group didn't take heparin infusion. Diffusion weighted magnetic resonance imaging (DWI-MRI) and gradient echo (GRE) sequences performed in all patients at the 24 h of carotid stenting.Early serebral silent ischemia was detected by DWI-MRI in 13 (50%) of 26 patients who underwent carotid stenting. Seven (53.80%) of 13 patients whit early serebral silent ischemia did not receive heparin treatment, while 6 (46.20%) received heparin treatment. There was no symptomatic or asymptomatic acute hemorrhage in patients who treated with heparin.In our study, the continuation of anticoagulant therapy for 24 h to prevent early silent ischemia was not statistically significant. Also there is no reduction for count of serebral silent ischemia between two groups. However, due to the small number of patients in the study, future studies are required with more patients. |
| Databáze: | OpenAIRE |
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