Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone
| Autor: | Itaru Takamisawa, Masaaki Suzuki, Yutaka Harano, Yasunao Yoshimasa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Vasodilation Type 2 diabetes Nitroglycerin Endocrinology Insulin resistance Diabetes mellitus medicine.artery Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Insulin Endothelial dysfunction Brachial artery Aged Pioglitazone business.industry General Medicine medicine.disease Diabetes Mellitus Type 2 cardiovascular system Female Thiazolidinediones Endothelium Vascular Insulin Resistance business medicine.drug |
| Zdroj: | Diabetes Research and Clinical Practice. 76:12-17 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2006.07.033 |
| Popis: | Endothelial dysfunction is regarded as an early stage of atherosclerosis, and plays a role in the development of atherosclerotic diseases. Insulin resistance is related to the atherosclerotic process. In this study, we examined the association between endothelial function and insulin resistance in 48 subjects with type 2 diabetes. In addition, the effects of pioglitazone treatment on endothelial function and insulin resistance were investigated in a subgroup of subjects. Endothelial function of the brachial artery was non-invasively assessed using ultrasound technique. We measured flow-mediated endothelium-dependent vasodilation (FMD) and glyceryl trinitrate-induced endothelium-independent vasodilation (GTN). Insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. High SSPG levels indicate insulin resistance. There was a significant inverse correlation (r=-0.462, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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