A double-blind randomized placebo control study comparing the objective and subjective changes in female sexual response using sublingual apomorphine
| Autor: | Maria Victoria Bertolino, Adolfo Casabé, N. Fredotovich, Amado Bechara |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Apomorphine Urology Endocrinology Diabetes and Metabolism media_common.quotation_subject Sexual arousal Sexual Behavior Female sexual dysfunction Administration Sublingual Orgasm Placebo Arousal law.invention Placebos Endocrinology Randomized controlled trial law Internal medicine medicine Humans Prospective Studies media_common Cross-Over Studies medicine.disease Crossover study Surgery Psychiatry and Mental health Sexual Dysfunction Physiological Sexual dysfunction Treatment Outcome Reproductive Medicine Dopamine Agonists Female medicine.symptom Psychology |
| Zdroj: | The journal of sexual medicine. 1(2) |
| ISSN: | 1743-6095 |
| Popis: | Introduction Female sexual dysfunction and its therapeutic approach is a growing area. Aim We aimed to assess the subjective and objective changes of the female sexual response, in patients with orgasmic sexual dysfunction using 3 mg SL Apomorphine (APO). Methods Twenty‐four patients (mean age 32 years old, SD: 9.69) were included in a prospective randomized cross‐over protocol. Sexual response was evaluated objectively (duplex ultrasound) and subjectively (self‐reported questionnaire) following vibrator stimuli with the addition of 3 mg SL APO or placebo. Main Outcome Measure Sexual response objective (PSV, EDV, RI) and subjective (arousal and lubrication degree and orgasm achievement). Adverse events were also recorded. Results Clitoral hemodynamical changes, particularly peak systolic velocity (PSV), were significantly higher with APO ( P = 0.003), mean increase of PSV poststimulus was 72.50% with placebo (from 9.7 cm/second to 17.0 cm/second) and 139.14% with APO (from 9.7 cm/second to 21.4 cm/second). Subjective changes (arousal and lubrication) were also significative with APO ( P Conclusion According to our observations, APO seemed to produce more subjective and objective changes in the sexual arousal phase of women with orgasmic sexual dysfunction than placebo. Future research is needed to evaluate the place of this drug in the treatment of the female sexual dysfunction. |
| Databáze: | OpenAIRE |
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