Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue
| Autor: | Masamichi Hayashi, Yasuhiro Kodera, Yuki Sunagawa, Suguru Yamada, Goro Nakayama, Nobuhiko Nakagawa, Fuminori Sonohara, Masahiko Koike, Raju Kandimalla, Yoshikuni Inokawa, Chie Tanaka, Mitsuro Kanda, Hideki Takami, Katsuhito Tanaka |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research Adenosine Carcinoma Hepatocellular medicine.medical_treatment AlkB Alpha-Ketoglutarate-Dependent Dioxygenase FTO Kaplan-Meier Estimate Methylation 03 medical and health sciences 0302 clinical medicine Liver tissue medicine Humans Aged Proportional Hazards Models Aged 80 and over biology business.industry Liver Neoplasms Significant difference AlkB Homolog 5 RNA Demethylase RNA General Medicine Middle Aged Prognosis medicine.disease Survival Analysis digestive system diseases Gene Expression Regulation Neoplastic Liver Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Multivariate Analysis biology.protein Cancer research Demethylase Female Cancer development Hepatectomy business |
| Zdroj: | Anticancer Research. 40:6665-6676 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14690 |
| Popis: | BACKGROUND/AIM N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. MATERIALS AND METHODS We analyzed 177 HCC and paired noncancerous liver tissues from patients who underwent hepatectomy according to global m6A quantification and expression of m6A demethylases fat mass and obesity-associated protein (FTO) and alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5). RESULTS The global m6A quantification revealed no significant difference between HCC and non-cancerous tissue. The expression of m6A demethylases FTO and ALKBH5, was significantly lower in HCC than in non-cancerous tissues (both p |
| Databáze: | OpenAIRE |
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