Risk factors associated with the persistence of human papillomavirus after cervical excision in patients with high-grade squamous intra-epithelial neoplasia
| Autor: | Jiahe Huang, Jufan Zhu, Yan Hu, Lejing Zang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Uterine Cervical Neoplasms Disease Alphapapillomavirus Logistic regression Gastroenterology Persistence (computer science) Risk Factors Internal medicine Humans Medicine Human papillomavirus Papillomaviridae Retrospective Studies Human papillomavirus 16 Human papillomavirus 18 business.industry Papillomavirus Infections HPV infection Infant Obstetrics and Gynecology Retrospective cohort study Odds ratio Uterine Cervical Dysplasia medicine.disease Confidence interval Reproductive Medicine Child Preschool Carcinoma Squamous Cell Female business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 266:175-181 |
| ISSN: | 0301-2115 |
| Popis: | OBJECTIVE To evaluate risk factors associated with the persistence of human papillomavirus (HPV) after cervical excision in patients with high-grade squamous intra-epithelial neoplasia (HSIL). METHODS A retrospective cohort study enrolled 550 patients who underwent cervical excision for HSIL between January 2015 and January 2018. The effects of various factors were assessed using univariate and multi-variate analyses. RESULTS The mean age of patients was 42.6 [standard deviation (SD) 8.7, range 22-64] years, and the mean duration of follow-up was 29.0 (SD 4.8, range 24-36) months. Persistent HPV infection after cone excision was detected in 78 (14.2%) patients. Univariate logistic regression analysis revealed that advanced age (>35 years), menopausal status, HPV type (HPV16/18), abnormal vaginal micro-ecological morphology, type of excision (loop electrosurgical excision procedure) and positive margin were closely associated with the persistence of HPV. Multi-variate analysis indicated that menopausal status [odds ratio (OR) 4.708, 95% confidence interval (CI) 2.770-8.001; p |
| Databáze: | OpenAIRE |
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