Three new tetralol analogs from soil-derived fungus Myrothecium verrucaria with anti-inflammatory activity
| Autor: | Shao-Fei Chen, Ming-Xu Tang, Gang Chen, Yue-Hu Pei, Xia-Nan Sang, Yu-Bo Wang, Ying-Ying Si, Lu Liu, Hai-Feng Wang, Xiao-Jie Lu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.drug_class
Anti-Inflammatory Agents Pharmaceutical Science HL-60 Cells Fungus 01 natural sciences Anti-inflammatory Analytical Chemistry Microbiology Drug Discovery medicine Humans Cytotoxicity Soil Microbiology Tetralones Pharmacology biology 010405 organic chemistry Chemistry Organic Chemistry Anti inflammation General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Soil fungus Hypocreales Molecular Medicine Myrothecium verrucaria |
| DOI: | 10.6084/m9.figshare.5947582 |
| Popis: | Three new tetralol analogs, myrochromanols A-C (1–3), together with 11 known trichothecenes (4–14), were isolated from a soil fungus Myrothecium verrucaria HL-P-1. The structures of the three new compounds were elucidated by extensive spectroscopic analysis including HRESIMS, NMR, and ECD calculation. All of the new compounds were tested for their anti-inflammatory activity and cytotoxicity. Compounds 1 and 3 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells with IC50 values of 26.04 and 25.80 μM, respectively. Three new tetralol analogs were isolated from a soil fungus Myrothecium verrucaria HL-P-1. All of them were tested for their anti-inflammatory and cytotoxicity activity. |
| Databáze: | OpenAIRE |
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