A unique immune signature of serum cytokine and chemokine dynamics in patients with Zika virus infection from a tropical region in Southern Mexico
| Autor: | Alfredo Cruz-Lagunas, Manuel Castillejos, Luis Alejandro Fernández-López, Sandra Caballero-Sosa, Pablo F. Belaunzarán-Zamudio, Salvador Fonseca-Coronado, Luis Jiménez-Alvarez, Justino Regalado, Mary Smolskis, Aminadab Goodina, Gustavo Ramírez-Martínez, Gabriel Nájera-Cancino, Héctor Vivanco-Cid, Joaquín Zúñiga, Carlos Cabello, Criselda Mendoza-Milla, Andres Hernandez, Erika Mariana Hernández-Montiel, Héctor Armando Rincón-León, Guillermo M. Ruiz-Palacios, John H. Beigel, Lourdes Guerrero, Santiago Pérez-Patrigeon, Alejandro Escobar-Gutiérrez, José Alberto Choreño-Parra, María Fernanda Cabrera-Cornejo, Nora E. Regino-Zamarripa, José Eduardo Márquez-García, Allyson Mateja, Sally Hunsberger |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Chemokine 030106 microbiology CCL3 Disease CCL2 Article CCL5 Zika virus lcsh:Infectious and parasitic diseases Cohort Studies 03 medical and health sciences 0302 clinical medicine Immune system Humans CXCL10 Medicine lcsh:RC109-216 030212 general & internal medicine Interleukin 8 Mexico biology Zika Virus Infection business.industry Interleukin-8 Acute infection General Medicine Inflammatory profile Interleukin 1 Receptor Antagonist Protein Infectious Diseases Immunology biology.protein Cytokines Female Chemokines Clinical symptoms business |
| Zdroj: | International Journal of Infectious Diseases, Vol 94, Iss, Pp 4-11 (2020) International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Objectives To describe the kinetics of circulating cytokines and chemokines in humans with ZIKAV infection. Methods Serum levels of different immune mediators in patients with ZIKAV infection were measured at distinct stages of the disease, as well as in culture supernatants from human monocytes infected with a clinical ZIKAV isolate. We also looked for clinical features associated with specific immune signatures among symptomatic patients. Results We evaluated 23 ZIKAV-infected patients. Their mean age was 32 ± 8.3 years and 65% were female. ZIKAV patients showed elevated IL-9, IL-17A, and CXCL10 levels at acute stages of the disease. At day 28, levels of CCL4 and CCL5 were increased, whereas IL-1RA, CXCL8 and CCL2 were decreased. At baseline, IL-7 was increased among patients with headache, whereas CCL2, and CCL3 were decreased in patients with bleeding and rash, respectively. Our clinical ZIKAV isolate induced a broad immune response in monocytes that did not resemble the signature observed in ZIKAV patients. Conclusions We showed a unique immune signature in our cohort of ZIKAV-infected patients. Our study may provide valuable evidence helpful to identify immune correlates of protection against ZIKAV. |
| Databáze: | OpenAIRE |
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