Intrasession Repeatability and Interocular Symmetry of Foveal Avascular Zone and Retinal Vessel Density in OCT Angiography
| Autor: | Moreno Menghini, Alex Hansen, David A. Mackey, Danuta M. Sampson, Ian J. Constable, Fred K. Chen |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
coefficient of repeatability Biomedical Engineering retinal capillary density limits of agreement 03 medical and health sciences 0302 clinical medicine Foveal split- spectrum amplitude decorrelation angiography Image resolution retinal angiography Physics business.industry Limits of agreement Parafovea Repeatability Foveal avascular zone Articles normative data test–retest variability Retinal vessel Ophthalmology 030104 developmental biology 030221 ophthalmology & optometry Symmetry (geometry) Nuclear medicine business OCTA |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose To measure intrasession repeatability and interocular symmetry of the foveal avascular zone area (FAZA) and superficial retinal vessel density (SRVD) using AngioVue Analytics optical coherence tomography angiography (OCTA). Methods Fifty healthy individuals were prospectively enrolled. OCTA scans (3 × 3 and 6 × 6 mm) were acquired twice in right and once in left eyes. FAZA (with and without rescaling) and SRVD for 18 regions (whole, fovea, parafovea, six parafoveal subregions, and nine square zones) were compared between two scans in right eyes (repeatability) and between both eyes (symmetry). Coefficients of repeatability (CRs) and limits of agreement (LAs) were calculated. Results Axial length-based image size rescaling had negligible impact on the intrasession CR of FAZA in both 3 × 3- and 6 × 6-mm images. The intrasession CRs for the foveal SRVD were 3.3% and 6.1% in the 3 × 3- and 6 × 6-mm OCTA images, respectively. Age and axial length did not influence test-retest variability of FAZA or SRVD. The interocular LAs in FAZA (0.039-0.059 mm2) was comparable to its CR. However, the interocular LAs in foveal SRVD were -4.5% to +3.8%, with 13% of the cohort showing an interocular difference greater than the CR. Conclusions FAZA repeatability is not influenced by image size correction, and foveal SRVD is more variable in 6 × 6- than 3 × 3-mm OCTA images. Low image quality may contribute to interocular SRVD asymmetry. Translational relevance CRs and LAs can be used to set a threshold for true changes in FAZA and SRVD in longitudinal studies of healthy individuals. |
| Databáze: | OpenAIRE |
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