Equine insect bite hypersensitivity: what do we know?
| Autor: | Jozef Janda, Eman Hamza, Eliane Isabelle Marti, Anna Schaffartzik, Reto Crameri, Claudio Rhyner |
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| Přispěvatelé: | University of Zurich, Marti, E |
| Rok vydání: | 2012 |
| Předmět: |
Allergy
040301 veterinary sciences Regulatory T cell medicine.medical_treatment 3400 General Veterinary Immunology Dermatitis 610 Medicine & health Cross Reactions Ceratopogonidae Immunoglobulin E T-Lymphocytes Regulatory 0403 veterinary science 03 medical and health sciences Th2 Cells 0302 clinical medicine Immune system Antigen 10183 Swiss Institute of Allergy and Asthma Research medicine Animals Simuliidae Horses Salivary Proteins and Peptides Antigen-presenting cell 2403 Immunology General Veterinary biology Insect Bites and Stings 04 agricultural and veterinary sciences Immunotherapy Allergens Culicoides biology.organism_classification medicine.disease 3. Good health medicine.anatomical_structure biology.protein Insect Proteins Horse Diseases 030215 immunology |
| Zdroj: | Veterinary immunology and immunopathology VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY |
| DOI: | 10.1016/j.vetimm.2012.03.017 |
| Popis: | Insect bite hypersensitivity (IBH) is an allergic dermatitis of the horse caused by bites of insects of the genus Culicoides and is currently the best characterized allergic disease of horses. This article reviews knowledge of the immunopathogenesis of IBH, with a particular focus on the causative allergens. Whereas so far hardly any research has been done on the role of antigen presenting cells in the pathogenesis of IBH, recent studies suggest that IBH is characterized by an imbalance between a T helper 2 (Th2) and regulatory T cell (T(reg)) immune response, as shown both locally in the skin and with stimulated peripheral blood mononuclear cells. Various studies have shown IBH to be associated with IgE-mediated reactions against salivary antigens from Culicoides spp. However, until recently, the causative allergens had not been characterized at the molecular level. A major advance has now been made, as 11 Culicoides salivary gland proteins have been identified as relevant allergens for IBH. Currently, there is no satisfactory treatment of IBH. Characterization of the main allergens for IBH and understanding what mechanisms induce a healthy or allergic immune response towards these allergens may help to develop new treatment strategies, such as immunotherapy. |
| Databáze: | OpenAIRE |
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