Prognostic value of the immunohistochemical expression of vascular endothelial growth factors in malignant salivary gland neoplasms: a systematic review and meta-analysis
| Autor: | J-C Ramos, A-G Normando, E. B. Dos Santos, A-F Leme |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Vascular Endothelial Growth Factor A medicine.medical_specialty Perineural invasion Review 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Biomarkers Tumor sex Humans General Dentistry Grading (tumors) UNESCO:CIENCIAS MÉDICAS tooth extraction Oral Medicine and Pathology Salivary gland business.industry Vascular Endothelial Growth Factors Hazard ratio Cancer 030206 dentistry medicine.disease Prognosis Salivary Gland Neoplasms Vascular endothelial growth factor molar Vascular endothelial growth factor A medicine.anatomical_structure Otorhinolaryngology chemistry Immunohistochemistry Surgery Neoplasm Recurrence Local business third |
| Zdroj: | Medicina Oral, Patología Oral y Cirugía Bucal dos Santos, ES., Ramos, JC., Normando, AG., & Leme, AF. (2021). Prognostic value of the immunohistochemical expression of vascular endothelial growth factors in malignant salivary gland neoplasms: a systematic review and meta-analysis. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e126-e135). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23974 |
| ISSN: | 1698-6946 |
| DOI: | 10.4317/medoral.23974 |
| Popis: | Background The immunohistochemical expression of vascular endothelial growth factor is a prognostic marker in several cancer types. In salivary gland tumors, the association between vascular endothelial growth factor and prognosis remains unclear. The purpose of this study was to perform a systematic review and meta-analysis to assess whether the immunohistochemical expression of vascular endothelial growth factor in patients with salivary gland neoplasms presents prognostic value. Material and Methods Immunohistochemical studies assessing the predictive value of vascular endothelial growth factor in salivary gland neoplasms were systematically reviewed using PubMed, Scopus, Embase, Cochrane Library, and Web of Science databases. It was assessed any survival rates. The fixed-effect model with an adjusted hazard ratio (HR) and 95% confidence intervals (95% CI) as effect measures were performed in the meta-analysis. The Quality in Prognosis Studies (QUIPS) tool was used to assess the quality of the included studies, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system. Results The immunohistochemical overexpression of vascular endothelial growth factor in patients with salivary gland neoplasms was associated with shortened survival (HR=5.37, 95% CI: 2.67-10.83, P = 0.00001). In addition, the presence of vascular endothelial growth factor was tightly associated with tumor size, lymph node metastasis, clinical stage, perineural invasion, vascular invasion, poor local control of the disease, and recurrence. Conclusions The immunohistochemical overexpression of vascular endothelial growth factor in patients with salivary gland neoplasms has prognostic value and was associated with decreased survival time. However, more primary well-designed studies are necessary to increase the level of evidence. Key words:Salivary gland neoplasms, salivary glands, head and neck neoplasms, vascular endothelial growth factors, prognosis. |
| Databáze: | OpenAIRE |
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