Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC
| Autor: | I.H. Ayhan, E. Ülkü, B. Uran, F.C. Tulunay, S. Kaymakçalan |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Pharmacology Drug Dose-Response Relationship Drug business.industry organic chemicals media_common.quotation_subject Drug Tolerance Hypothermia General Medicine Rats Dose–response relationship Drug tolerance Anesthesia mental disorders medicine Animals Dronabinol medicine.symptom Tetrahydrocannabinol business media_common medicine.drug |
| Zdroj: | Pharmacology. 21:391-395 |
| ISSN: | 1423-0313 0031-7012 |
| Popis: | The administration of 0.3-40 mg/kg delta 9-tetrahydrocannabinol (THC) produced a dose-dependent hypothermia in rats. The maximal hypothermic effect was obtained with the dose of 2.5 mg/kg of THC. When the same doses of THC were repeated on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism of these effects of THC is discussed. |
| Databáze: | OpenAIRE |
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