Spotting sporotrichosis skin infection: The first Australian paediatric case series
| Autor: | Anita J. Campbell, Anna Schauer, Christopher C Blyth, Ian Arthur, Asha C. Bowen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents Itraconazole Skin infection Dermatomycosis 03 medical and health sciences 0302 clinical medicine Interquartile range 030225 pediatrics Epidemiology Medicine Sporothrix schenckii Animals Humans 030212 general & internal medicine Child Retrospective Studies biology Sporotrichosis business.industry Sporothrix Australia Retrospective cohort study Western Australia medicine.disease biology.organism_classification Dermatology Pediatrics Perinatology and Child Health business medicine.drug |
| Zdroj: | Journal of paediatrics and child healthReferences. 56(3) |
| ISSN: | 1440-1754 |
| Popis: | AIM Sporotrichosis is a dermatomycosis caused by the dimorphic fungus, Sporothrix schenckii, with various outbreaks across Australia attributed to mouldy hay. Our objective was to investigate the clinical presentation and management of cutaneous sporotrichosis in a paediatric population of Western Australia. METHODS A retrospective case review was performed for S. schenckii infections in children below 18 years, between January 2000 and November 2017. Cases were identified from the state-wide laboratory database and additional clinical data obtained from medical records. RESULTS Thirty-two cases of microbiologically proven S. schenckii infection were identified, mostly from rural areas (n = 20, 63%). Complete clinical data were available for 11 cases (34%). The most common risk factors were exposure to farm animals and hay, arthropod bites and outdoor activities. The median duration from symptom onset to correct diagnosis was 6 weeks (interquartile range: 4-7 weeks). Most cases were initially treated with multiple, broad-spectrum antibacterial agents (n = 7, 64%). Targeted therapy (itraconazole) was used in all cases once the diagnosis was made, with a median treatment duration of 5 months (interquartile range: 4-6 months). Morbidity included scarring (n = 4, 31%), itraconazole associated diarrhoea (n = 1, 8%) and mild hepatotoxicity (n = 1, 8%). CONCLUSION Summarising the clinical experience of these cases is a useful guide for clinical recognition and may serve to shorten the interval between onset and diagnosis, and avoid the need for antibacterial therapy. These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting, leading to timely diagnosis and appropriate treatment with antifungal agents. |
| Databáze: | OpenAIRE |
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