Whipple’s disease diagnosed in a patient with suspected sarcoidosis
| Autor: | Alexander Zoufaly, Christoph Wenisch, Tamara Seitz, Sabine Hagenauer-Drektraan, David Totschnig |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Weight loss Anemia 030106 microbiology Lymph node biopsy Colonoscopy Lymphadenopathy Infectious and parasitic diseases RC109-216 Gastroenterology 03 medical and health sciences 0302 clinical medicine PAS Stain Internal medicine medicine 030212 general & internal medicine Whipple's disease Leukocytosis Chronic diarrhea medicine.diagnostic_test Thrombocytosis business.industry General Medicine medicine.disease Infectious Diseases Polyarthralgia Sarcoidosis Differential Leukocyte Count medicine.symptom Whipple’s disease business |
| Zdroj: | International Journal of Infectious Diseases, Vol 106, Iss, Pp 41-42 (2021) |
| ISSN: | 1201-9712 |
| Popis: | This paper presents a case of a 51-year-old patient with chronic diarrhea, weight loss, polyarthralgia, and diffuse lymphadenopathy. Laboratory work-up showed anemia, leukocytosis and thrombocytosis, and increased C-reactive protein (CRP). Due to an inconspicuous differential leukocyte count and lymph node biopsy findings showing granulomatous lymphadenopathy, sarcoidosis was initially suspected. Colonoscopy found no abnormalities and duodenal biopsies showed negative Periodic acid-Schiff stains. However, PCR testing on these biopsies revealed Tropheryma whipplei DNA. Further PCR testing of urine and cerebrospinal fluid also revealed T. whipplei DNA. The patient was treated with ceftriaxone for 2 weeks followed by trimethoprim for a year. A rapid improvement of his symptoms was seen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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