Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity
| Autor: | Yu-Sheng Cong, Danhua Zheng, Miao Wang, Lili Zhou |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Transcriptional Activation
Vascular Endothelial Growth Factor A Telomerase Transcription Genetic VEGF receptors Biophysics Biology medicine.disease_cause Biochemistry Catalysis Cell Line chemistry.chemical_compound Transcription (biology) medicine Humans Telomerase reverse transcriptase Molecular Biology Regulation of gene expression Cell Biology Telomere Vascular endothelial growth factor chemistry Cancer research biology.protein Endothelium Vascular Carcinogenesis HeLa Cells |
| Zdroj: | Biochemical and Biophysical Research Communications. 386:739-743 |
| ISSN: | 0006-291X |
| Popis: | Telomerase is almost universally required for cellular immortality and is permissive for tumorigenesis. Accumulating evidence suggests that telomerase may have roles in cellular processes independent of its role in telomere maintenance. However, the biochemical properties and the mechanisms of telomerase non-telomeric functions are unknown. In this report, we show that the telomerase catalytic component hTERT is capable of activating transcription of VEGF. We further demonstrated that the activation of VEGF expression by hTERT was independent of telomerase activity and telomere maintenance. These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer. |
| Databáze: | OpenAIRE |
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