Modifying Effects of Nanosized Diamonds on Hydrolytic Potential of Macrophages In Vitro
| Autor: | D. V. Neshchadim, V. A. Shkurupy, E. S. Akhramenko, A. V. Troitskii, M. A. Karpov, S. A. Arkhipov |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Cathepsin Male Mice Inbred BALB C Hydrolysis Macrophages Stimulation General Medicine Matrix metalloproteinase Cathepsins General Biochemistry Genetics and Molecular Biology In vitro Cell biology chemistry.chemical_compound Mice Enzyme chemistry Metalloproteases Macrophage Animals Nanoparticles Secretion Diamond Xenobiotic |
| Zdroj: | Bulletin of experimental biology and medicine. 159(3) |
| ISSN: | 1573-8221 |
| Popis: | The effects of nanosized particles (4–6 nm) of synthetic diamonds on mouse macrophage expression and secretion of lysosomal cathepsins (B and D) and MMP-1 and MMP-9 were studied in vitro. Culturing of peritoneal macrophages in medium with diamond nanoparticles led to an increase in the counts of macrophages expressing the above enzymes and to stimulation of their secretion. However, the manifestations of these effects varied significantly for various enzymes. The data indicate modulation of macrophage functions by nanodiamonds. These results help better understand the possible role of the “corpuscular” xenobiotic factors in the pathogenesis of diseases associated with macrophage capturing of these factors irrespective of their chemical “activity”. |
| Databáze: | OpenAIRE |
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