Ciprofloxacin carrier systems based on hectorite/halloysite hybrid hydrogels for potential wound healing applications
| Autor: | Marina Massaro, Giuseppina Sandri, Ana Borrego-Sánchez, Susanna Guernelli, Dalila Miele, C. Ignacio Sainz-Díaz, Giuseppe Lazzara, Fátima García-Villén, Serena Riela, Giuseppe Cavallaro, César Viseras Iborra, Rita Sánchez-Espejo |
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| Přispěvatelé: | Universidad de Granada, Junta de Andalucía, Ministerio de Economía y Competitividad (España), Massaro M., Borrego-Sanchez A., Sanchez-Espejo R., Viseras Iborra C., Cavallaro G., Garcia-Villen F., Guernelli S., Lazzara G., Miele D., Sainz-Diaz C.I., Sandri G., Riela S., Marina Massaro, Ana Borrego-Sánchez, Rita Sánchez-Espejo, César Viseras Iborra, Giuseppe Cavallaro, Fátima García-Villén, Susanna Guernelli, Giuseppe Lazzara, Dalila Miele, Ignacio Sainz-Díaz, Giuseppina Sandri, SerenaRiela |
| Rok vydání: | 2021 |
| Předmět: |
Supramolecular chemistry
Wound healing engineering.material Hybrid hydrogel Halloysite Settore CHIM/12 - Chimica Dell'Ambiente E Dei Beni Culturali Nanomaterials Geochemistry and Petrology medicine drug carrier Settore CHIM/02 - Chimica Fisica Chemistry Geology Settore CHIM/06 - Chimica Organica Ciprofloxacin Clay minerals Chemical engineering Covalent bond Self-healing hydrogels Hectorite engineering Drug carrie medicine.drug Clay minerals halloysite hectorite hybrid hydrogel wound healing drug carrier |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The design of multifunctional nanomaterials which can help the healing processes of skin, preventing the bacterial infections, is crucial for the development of suitable therapy for the treatment of chronic lesions. The use of clay minerals in wound healing applications is well documented since the prehistoric period and offers several advantages due to their intrinsic properties. Herein, we report the development of ciprofloxacin carrier systems based on hectorite/halloysite (Ht/Hal) hybrid hydrogels for potential wound healing applications. To achieve this objective firstly the ciprofloxacin molecules were loaded onto Hal by a supramolecular and covalent approach. The so obtained fillers were thoroughly investigated by several techniques and at molecular level by means of quantum mechanics calculations along with empirical interatomic potentials. Afterwards the modified Hal were used as filler for Ht hydrogels. The introduction of modified Hal, in hectorite hydrogel, helps the gel formation with an improvement of the rheological properties. The in vitro kinetic release from both the fillers and from the hybrid hydrogels was studied both at skin's pH (5.4) and under neutral conditions (pH 7.4); in addition, the factors controlling the ciprofloxacin release process were determined and discussed. Finally, the in vitro biocompatibility of the Hal fillers was evaluated by means of cytotoxic assays and laser scanning confocal microscopy on normal human dermal fibroblasts. The work was carried out in the frame of the PON “AIM: Attrazione e Mobilità Internazionale” No. 1808223-1 project. Authors are thankful to H.A. Duarte for providing atomic coordinates of halloysite, to the CSIC Computational Center and the University of Granada Computation Center for computation facilities, and the Andalusian project grants RNM-1897 and P18-RT-3786 , and the Spanish MINECO projects , PCIN-2017-098 , FIS2016-77692-C2-2-P and CGL2016-80833-R , for the financial support of this research. |
| Databáze: | OpenAIRE |
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