Increase of muscarinic cholinergic receptors in the rat submandibular glands after parasympathectomy and repeated administration of haloperidol
| Autor: | Omar R. Tumilasci, Jorge H. Medina, Jorge H. Pazo, S. Rascovsky, Diana Jerusalinsky |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Submandibular Gland In Vitro Techniques Parasympathectomy stomatognathic system Parasympathetic Nervous System Internal medicine Muscarinic acetylcholine receptor Haloperidol Animals Methacholine Compounds Medicine Sialogogue Pharmacology Denervation Dose-Response Relationship Drug business.industry Rats Inbred Strains Receptors Muscarinic Rats Quinuclidinyl Benzilate Kinetics Endocrinology Cholinergic Methacholine business medicine.drug |
| Zdroj: | General Pharmacology: The Vascular System. 20:759-761 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(89)90325-x |
| Popis: | 1. The mechanisms of the supersensitivity to cholinergic drugs after chronic haloperidol was studied in normal and parasympathectomized submandibular glands of the rats. 2. Both parasympathectomy and haloperidol treatment for 7 days (2 mg/kg/day, i.p.) increased the sialogogue response of the glands to methacholine, a cholinomimetic drug. 3. Both denervation and haloperidol administration induce up-regulation of the muscarinic receptors as expressed per gram of the tissue. 4. Haloperidol causes no further increase in sensitivity than denervation alone. 5. These data demonstrate that secretory supersensitivity to cholinergic drugs in the rat submandibular glands, after chronic haloperidol and parasympathectomy is related to an increase in muscarinic cholinergic receptors. |
| Databáze: | OpenAIRE |
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