Effect of light emitting diode photobiomodulation on murine macrophage function after Bothrops envenomation
| Autor: | Maria Naiara Macedo Tavares, Charles Nunes Boeno, Stella Regina Zamuner, Alex Augusto Ferreira e Ferreira, Valdison Pereira dos Reis, Sulamita da Silva Setúbal, Andreimar M. Soares, Juliana P. Zuliani, Cristina Matiele Alves Rego, Mauro Valentino Paloschi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cell Survival Interleukin-1beta Intracellular Space Snake Bites Venom Pharmacology Toxicology Nitric Oxide Nitric oxide 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Superoxides Crotalid Venoms Macrophage Medicine Animals Bothrops Low-Level Light Therapy Adverse effect Envenomation Incubation chemistry.chemical_classification Reactive oxygen species biology business.industry Macrophages General Medicine biology.organism_classification Interleukin-10 030104 developmental biology chemistry Semiconductors 030220 oncology & carcinogenesis business Reactive Oxygen Species |
| Zdroj: | Chemico-biological interactions. 333 |
| ISSN: | 1872-7786 |
| Popis: | Several reports have suggested that photobiomodulation, owing to its analgesic, anti-inflammatory, and healing effects, may be an effective therapeutic option for local effects of snakebites when the availability and accessibility of conventional serum therapy are inefficient and far from medical care centers. Although there have been studies that demonstrate the application of photobiomodulation in the treatment of local adverse events due to snakebites from snakes of the genus Bothrops, its role in the activation of leukocytes, particularly macrophages, has not been evaluated. Here, we assessed the effect of light-emitting diode (LED) treatment on macrophage activation induced by B. jararacussu venom (BjV). LED treatment caused an increase in the viability of macrophages incubated with BjV. This treatment reduced reactive oxygen species (ROS) and nitric oxide (NO) production by macrophages after incubation with BjV. However, LED treatment did not interfere with IL-1β and IL-10 production by macrophages after incubation with BjV. In conclusion, this study showed that LED treatment has the potential to be used in combination with conventional serum therapy to prevent or minimize the progression of local to severe symptoms after Bothrops envenomation. |
| Databáze: | OpenAIRE |
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