Acta Ophthalmol
| Autor: | Bénédicte M. J. Merle, Miguel Raimundo, Rufino Silva, Cécile Delcourt, Luisa Ribeiro, Cláudia Farinha, Sandrina Nunes, João Figueira, Inês Laíns, Maria Luz Cachulo, Patrícia Barreto, Lèlita Santos, Dalila Alves, Filipe Mira |
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| Přispěvatelé: | Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Rural Population medicine.medical_specialty Mediterranean diet medicine.medical_treatment Population Diet Mediterranean Risk Assessment LEHA Food group Macular Degeneration 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology Prevalence medicine Humans 030212 general & internal medicine education Life Style age-related macular degeneration Aged 2. Zero hunger education.field_of_study Portugal business.industry Vitamin E General Medicine Macular degeneration Prognosis medicine.disease Micronutrient 3. Good health Ophthalmology Cross-Sectional Studies nutrition Case-Control Studies Population Surveillance micronutrients 030221 ophthalmology & optometry Patient Compliance Female epidemiology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Risk assessment |
| Zdroj: | Acta Ophthalmologica Acta Ophthalmologica, 2018, 96 (8), pp.e926-e932. ⟨10.1111/aos.13775⟩ Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | PURPOSE: To characterize the lifestyle and nutritional risk profile associated with the Mediterranean diet in a Portuguese population with and without age-related macular degeneration (AMD). METHODS: Nested case-control study (n = 883) within the Coimbra Eye Study, including 434 subjects with AMD and 449 age- and sex-matched subjects without AMD. All enrolled subjects underwent a full risk assessment, including lifestyle-related risk factors and a thorough food frequency questionnaire. This allowed us to build an adherence score to the Mediterranean diet (mediSCORE, range 0-9) constructed from individual food intakes. Food intake was also further analysed by conversion to micronutrient consumption. RESULTS: Our results suggest that physical activity has a protective role in AMD [p = 0.018 after multivariate adjustment, OR: 0.69 (0.51-0.93)]. High (mediSCORE >/=6) was also found to be protective [p = 0.041, OR: 0.62 (95% CI: 0.38-0.97)]. Food group analysis unveiled a specific protective role for increased fruits consumption (p = 0.029). Finally, micronutrient analysis revealed a protective role associated with increased consumption of caffeine, fibres, beta-carotene, vitamin C and vitamin E (p < 0.05). CONCLUSION: High mediSCORE appears to confer protection against the development of AMD in a Mediterranean population. This effect is driven by increased consumption of fruits and some antioxidant micronutrients, which emerged as statistically significant protective factors. Further studies are required to establish dietary recommendations with clinical application. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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